Researchers find new way to enhance delivery of anticancer drugs
Korean researchers have found a way to enhance the delivery of anticancer drugs... by targeting the blood vessels that feed cancerous tissues.
Park Se-young has the details.
Cancer cells form blood vessels around them to receive oxygen and nutrients.
However, cancerous blood vessels are structurally and functionally abnormal, so blood or oxygen flows poorly compared to normal blood vessels.
This hampers the effects of anticancer drugs.
The Korean research team found that normalizing the blood vessels increased the oxygen supply in cancerous tissues and slowed the growth of cancer.
It also enhanced the effectiveness of existing anticancer drugs, reducing the size of tumors by 40 percent and increasing survival rates by 42 percent based on tests in mice.
"This enhances the delivery and effectiveness of existing drugs, so a lower dose is sufficient for treatment. Immune cells can also function normally."
In reaching their conclusion, the team also discovered for the first time the core genes that promote the creation of these cancerous blood vessels.
The researchers believe their treatment method, when combined with existing techniques, will be able to heighten the cancer-fighting effects of both.